Chemoproteomics/Chemical Biology

• Drug screening against functional proteomes (such as kinases, and deubiquitinating enzymes)
• Target identification of drug candidates and natural products
• Protein-small molecule compound interaction
• Investigation of fundamental biology with small-molecule ligands/inhibitors

Proteomics

• Methodology to decipher protein translational modifications (PTMs, e.g., ubiquitylation, glycosylation, and phosphorylation) and PTM crosstalk
• Targeted assay development for clinical (glycol)protein biomarkers
• Protein biomarker discovery for diagnosis and treatment